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16,17-bond,. File Format: Microsoft Word - View as HTML Inhibition of drug metabolism by cytokines and nitric oxide.. Study on the tandem Michael-aldol reaction utilizing chalcogen compounds. We showed that generic drug-masking groups can be selectively removed by sequential reactions catalyzed by antibody 38C2 (Fig. 4).. The activation sequence catalyzed by 38C2 is depicted for the drug-masking linker. Catalytic cleavage of the trigger by (more.). . are Neuroscience Letters an extremely important sub-structure in small molecule drug development.. The tandem and aldol-aldol reactions

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